Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
9
We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
Read More
9
We conducted a study to see how vitamin D3 supplementation affects rheumatoid arthritis (RA), particularly focusing on disease activity and fatigue. In our research design, we organized a randomized clinical trial at rheumatology clinics in Tripoli, Libya, involving patients who were already on conventional disease-modifying antirheumatic drugs (DMARDs).
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
Read More
9
We explored the effects of 20-hydroxyvitamin D3 (20(OH)D3) on rheumatoid arthritis (RA) in a mouse model. Unlike vitamin D3, which can have harmful effects on the body's calcium levels, 20(OH)D3 offers a noncalcemic alternative that shows promise for chronic treatment of RA.
Our findings demonstrated that 20(OH)D3 significantly suppressed clinical signs of arthritis and reduced joint damage. We observed a decrease in harmful lymphocyte subsets, such as CD4 T cells and CD19 B cells, which are responsible for inflammatory responses in RA. Notably, treatment with 20(OH)D3 resulted in a better balance of regulatory T cells compared to other T cell types, and also a reduction in anti-CII antibodies, critical players in joint damage.
The results of this study suggest that by lowering pro-inflammatory cytokines and antibodies, 20(OH)D3 effectively shields the cartilage and bone from destruction. This positions 20(OH)D3 as a potential candidate for treating RA and possibly other autoimmune disorders, warranting further investigation.
Our findings demonstrated that 20(OH)D3 significantly suppressed clinical signs of arthritis and reduced joint damage. We observed a decrease in harmful lymphocyte subsets, such as CD4 T cells and CD19 B cells, which are responsible for inflammatory responses in RA. Notably, treatment with 20(OH)D3 resulted in a better balance of regulatory T cells compared to other T cell types, and also a reduction in anti-CII antibodies, critical players in joint damage.
The results of this study suggest that by lowering pro-inflammatory cytokines and antibodies, 20(OH)D3 effectively shields the cartilage and bone from destruction. This positions 20(OH)D3 as a potential candidate for treating RA and possibly other autoimmune disorders, warranting further investigation.
Read More
Most Useful Reviews
9
Significant symptom relief
Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement.
Read More
8
Effective joint support
I've been purchasing this remedy for several years for the preventive care of joints for individuals with rheumatoid arthritis. It genuinely works and effectively complements the main treatment as a joint support agent. I highly recommend it.
Read More
7
Calcium supplements essential
I take the medication regularly throughout the year and can confidently recommend it. My calcium levels remain normal, and I notice my nails grow more actively. I require calcium supplements daily due to my rheumatoid arthritis, as the medications I take deplete calcium from my body. After having total knee joint replacements, calcium is crucial for the durability of my prostheses. I've tried various calcium preparations, but I continue with this one that includes vitamin D. Another advantage is that it is calcium citrate, which is better absorbed by the body.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
- All Researches
9
We conducted a study to see how vitamin D3 supplementation affects rheumatoid arthritis (RA), particularly focusing on disease activity and fatigue. In our research design, we organized a randomized clinical trial at rheumatology clinics in Tripoli, Libya, involving patients who were already on conventional disease-modifying antirheumatic drugs (DMARDs).
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
Read More
9
We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
Read More
9
We explored the effects of 20-hydroxyvitamin D3 (20(OH)D3) on rheumatoid arthritis (RA) in a mouse model. Unlike vitamin D3, which can have harmful effects on the body's calcium levels, 20(OH)D3 offers a noncalcemic alternative that shows promise for chronic treatment of RA.
Our findings demonstrated that 20(OH)D3 significantly suppressed clinical signs of arthritis and reduced joint damage. We observed a decrease in harmful lymphocyte subsets, such as CD4 T cells and CD19 B cells, which are responsible for inflammatory responses in RA. Notably, treatment with 20(OH)D3 resulted in a better balance of regulatory T cells compared to other T cell types, and also a reduction in anti-CII antibodies, critical players in joint damage.
The results of this study suggest that by lowering pro-inflammatory cytokines and antibodies, 20(OH)D3 effectively shields the cartilage and bone from destruction. This positions 20(OH)D3 as a potential candidate for treating RA and possibly other autoimmune disorders, warranting further investigation.
Our findings demonstrated that 20(OH)D3 significantly suppressed clinical signs of arthritis and reduced joint damage. We observed a decrease in harmful lymphocyte subsets, such as CD4 T cells and CD19 B cells, which are responsible for inflammatory responses in RA. Notably, treatment with 20(OH)D3 resulted in a better balance of regulatory T cells compared to other T cell types, and also a reduction in anti-CII antibodies, critical players in joint damage.
The results of this study suggest that by lowering pro-inflammatory cytokines and antibodies, 20(OH)D3 effectively shields the cartilage and bone from destruction. This positions 20(OH)D3 as a potential candidate for treating RA and possibly other autoimmune disorders, warranting further investigation.
Read More
8
Calcitriol improves immune function in RA
We investigated how calcitriol, a form of vitamin D3, influences the immune response in rheumatoid arthritis (RA). In this study, rheumatoid arthritis was induced in BALB/c mice, allowing us to assess the effectiveness of calcitriol-treated mesenchymal stem cells (MSCs) compared to untreated ones. This involved dividing the mice into three groups: one without treatment, one receiving untreated MSCs, and the last treated with calcitriol-exposed MSCs.
Our findings showed that calcitriol treatment significantly improved the regulatory functions of immune cells, particularly splenocytes. In particular, we observed enhanced safety and reduced levels of inflammatory mediators associated with RA. Furthermore, the production of cytokines like IL-4, IL-10, and TGF-β increased, while INF-γ and IL-17 levels decreased in animals treated with calcitriol. This suggests that vitamin D3 could play a promising role in moderating the immune response in RA patients.
Overall, our study highlights the potential of calcitriol in creating effective treatment pathways for rheumatoid arthritis, addressing existing challenges in managing this chronic inflammatory condition.
Our findings showed that calcitriol treatment significantly improved the regulatory functions of immune cells, particularly splenocytes. In particular, we observed enhanced safety and reduced levels of inflammatory mediators associated with RA. Furthermore, the production of cytokines like IL-4, IL-10, and TGF-β increased, while INF-γ and IL-17 levels decreased in animals treated with calcitriol. This suggests that vitamin D3 could play a promising role in moderating the immune response in RA patients.
Overall, our study highlights the potential of calcitriol in creating effective treatment pathways for rheumatoid arthritis, addressing existing challenges in managing this chronic inflammatory condition.
Read More
8
We aimed to understand how vitamin D3, both in its active form (1,25-dihydroxyvitamin D3) and a non-calcemic variant (20-hydroxyvitamin D3), influences rheumatoid arthritis. Using a collagen-induced arthritis model in mice, we compared the severity of arthritis in vitamin D-deficient versus normal diet groups.
Our findings indicated that mice with vitamin D deficiency experienced more severe arthritis symptoms characterized by higher levels of inflammatory cytokines produced by T cells. However, when we cultured these T cells with 20(OH)D3, there was a notable suppression of those inflammatory responses.
A significant discovery was that both forms of vitamin D3 led to an increase in LAIR-1, a natural receptor that inhibits immune responses. We noted that activating LAIR-1 with specific antibodies also reduced arthritis symptoms. Interestingly, treatment with vitamin D was effective in mice that had LAIR-1 but not in those lacking this receptor, suggesting LAIR-1 plays a crucial role in how vitamin D helps regulate inflammation.
Overall, our data support the idea that vitamin D, particularly the non-calcemic 20(OH)D3, can be a promising option in treating autoimmune diseases like rheumatoid arthritis, leveraging its effects on LAIR-1.
Our findings indicated that mice with vitamin D deficiency experienced more severe arthritis symptoms characterized by higher levels of inflammatory cytokines produced by T cells. However, when we cultured these T cells with 20(OH)D3, there was a notable suppression of those inflammatory responses.
A significant discovery was that both forms of vitamin D3 led to an increase in LAIR-1, a natural receptor that inhibits immune responses. We noted that activating LAIR-1 with specific antibodies also reduced arthritis symptoms. Interestingly, treatment with vitamin D was effective in mice that had LAIR-1 but not in those lacking this receptor, suggesting LAIR-1 plays a crucial role in how vitamin D helps regulate inflammation.
Overall, our data support the idea that vitamin D, particularly the non-calcemic 20(OH)D3, can be a promising option in treating autoimmune diseases like rheumatoid arthritis, leveraging its effects on LAIR-1.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant symptom relief
Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement.
Read More
8
Effective joint support
I've been purchasing this remedy for several years for the preventive care of joints for individuals with rheumatoid arthritis. It genuinely works and effectively complements the main treatment as a joint support agent. I highly recommend it.
Read More
7
Calcium supplements essential
I take the medication regularly throughout the year and can confidently recommend it. My calcium levels remain normal, and I notice my nails grow more actively. I require calcium supplements daily due to my rheumatoid arthritis, as the medications I take deplete calcium from my body. After having total knee joint replacements, calcium is crucial for the durability of my prostheses. I've tried various calcium preparations, but I continue with this one that includes vitamin D. Another advantage is that it is calcium citrate, which is better absorbed by the body.
Read More
Frequently Asked Questions
9
Significant symptom relief
Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement.
8
Effective joint support
I've been purchasing this remedy for several years for the preventive care of joints for individuals with rheumatoid arthritis. It genuinely works and effectively complements the main treatment as a joint support agent. I highly recommend it.
7
Calcium supplements essential
I take the medication regularly throughout the year and can confidently recommend it. My calcium levels remain normal, and I notice my nails grow more actively. I require calcium supplements daily due to my rheumatoid arthritis, as the medications I take deplete calcium from my body. After having total knee joint replacements, calcium is crucial for the durability of my prostheses. I've tried various calcium preparations, but I continue with this one that includes vitamin D. Another advantage is that it is calcium citrate, which is better absorbed by the body.
8
Calcitriol improves immune function in RA
We investigated how calcitriol, a form of vitamin D3, influences the immune response in rheumatoid arthritis (RA). In this study, rheumatoid arthritis was induced in BALB/c mice, allowing us to assess the effectiveness of calcitriol-treated mesenchymal stem cells (MSCs) compared to untreated ones. This involved dividing the mice into three groups: one without treatment, one receiving untreated MSCs, and the last treated with calcitriol-exposed MSCs.
Our findings showed that calcitriol treatment significantly improved the regulatory functions of immune cells, particularly splenocytes. In particular, we observed enhanced safety and reduced levels of inflammatory mediators associated with RA. Furthermore, the production of cytokines like IL-4, IL-10, and TGF-β increased, while INF-γ and IL-17 levels decreased in animals treated with calcitriol. This suggests that vitamin D3 could play a promising role in moderating the immune response in RA patients.
Overall, our study highlights the potential of calcitriol in creating effective treatment pathways for rheumatoid arthritis, addressing existing challenges in managing this chronic inflammatory condition.
Our findings showed that calcitriol treatment significantly improved the regulatory functions of immune cells, particularly splenocytes. In particular, we observed enhanced safety and reduced levels of inflammatory mediators associated with RA. Furthermore, the production of cytokines like IL-4, IL-10, and TGF-β increased, while INF-γ and IL-17 levels decreased in animals treated with calcitriol. This suggests that vitamin D3 could play a promising role in moderating the immune response in RA patients.
Overall, our study highlights the potential of calcitriol in creating effective treatment pathways for rheumatoid arthritis, addressing existing challenges in managing this chronic inflammatory condition.
9
We conducted a study to see how vitamin D3 supplementation affects rheumatoid arthritis (RA), particularly focusing on disease activity and fatigue. In our research design, we organized a randomized clinical trial at rheumatology clinics in Tripoli, Libya, involving patients who were already on conventional disease-modifying antirheumatic drugs (DMARDs).
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
Participants were split into two groups: one group received a weekly boost of 50,000 IU of vitamin D3, while the other group continued their treatment without any vitamin D3 supplementation. Over a period of 12 weeks, we monitored changes in their symptoms and overall well-being.
Our results revealed something quite remarkable. The group taking vitamin D3 reported notable improvements in fatigue levels compared to those who did not receive the supplement. Specifically, the patients receiving vitamin D3 achieved normal fatigue scores, suggesting their energy levels were significantly better. Additionally, we observed a positive link between higher vitamin D levels and a reduction in fatigue symptoms.
However, there wasn't a significant change in measures of disease activity, indicating that while vitamin D3 can help with fatigue, it may not directly influence the disease's inflammatory aspects in RA patients. Overall, the findings highlight vitamin D3's role in improving the quality of life for individuals battling rheumatoid arthritis through alleviation of fatigue, even when their disease activity remains unchanged.
9
We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
References
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
- Elfituri S. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients. Reumatologia. 2024;62:109. 10.5114/reum/187391
- Huovinen J, Palosaari S, Pesonen P, Huhtakangas JA, Lehenkari P. 1,25(OH)D and its analogue calcipotriol inhibit the migration of human synovial and mesenchymal stromal cells in a wound healing model - A comparison with glucocorticoids. J Steroid Biochem Mol Biol. 2023;233:106373. 10.1016/j.jsbmb.2023.106373
- Zhu W, Zhu Y, Zhang S, Zhang W, Si Z, et al. 1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. J Steroid Biochem Mol Biol. 2023;228:106251. 10.1016/j.jsbmb.2023.106251
- Zou J, Zhu L, Yang J, Feng J, Li S, et al. Correlation between vitamin D metabolites and rheumatoid arthritis with osteoporosis by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). J Bone Miner Metab. 2022;40:696. 10.1007/s00774-022-01337-3
- Sakalyte R, Denkovskij J, Bernotiene E, Stropuviene S, Mikulenaite SO, et al. The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis. Front Immunol. 2021;12:767512. 10.3389/fimmu.2021.767512
- Myers LK, Winstead M, Kee JD, Park JJ, Zhang S, et al. 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis. Int J Mol Sci. 2021;22. 10.3390/ijms222413342
- Postlethwaite AE, Tuckey RC, Kim TK, Li W, Bhattacharya SK, et al. 20-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis. Front Immunol. 2021;12:678487. 10.3389/fimmu.2021.678487
- Dobrovolskaya OV, Toroptsova NV, Nikitinskaya OA, Samarkina EY, Cherkasova MV, et al. [Vitamin D status in women with rheumatoid arthritis: frequency of hypovitaminosis, associations with disease activity, body composition and comorbidity]. Ter Arkh. 2021;93:581. 10.26442/00403660.2021.05.200790
- Hemshekhar M, Anaparti V, El-Gabalawy H, Mookherjee N. A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis. Arthritis Res Ther. 2021;23:39. 10.1186/s13075-021-02423-z
